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科学研究中心科研成果
时间:2019.08.13
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来源:吉林大学中日联谊医院

近年来,科室科研工作取得了多项重要成果。其中,承担国家级项目9项,累积科研经费200万;省级52项,累积科研经费783万;横项课题3项,累积科研经费260万;校级及其他项目累积科研经费70余万。获得省级科研奖项8项、校级2项。发表科研论文共计163篇,其中中文文章86篇,英文文章78篇。2018年来,科室于微尺度诊疗等新兴交叉科研领域取得了阶段性研究成果,在干细胞治疗、肿瘤光热治疗、肿瘤磁靶向治疗等研究领域发表了多篇高水平文章,其中以第一作者或通讯作者发表文章影响因子累计136.451。


2013-2020年科研论著发表情况


1. Fe3O4@polydopamine Composite Theranostic Superparticles Employing Preassembled Fe3O4Nanoparticles as the Core,2016,姜金兰,ACS Appl Mater Interfaces,IF=7.505,工程技术1区


2. Polydopamine-coated Au-Ag nanoparticle-guided photothermal colorectal cancer therapy through multiple cell death pathways,2019,郝苗,姜金兰*,Acta Biomaterialia,IF=6.638,工程技术1区,生物材料2区


3. NaYF4:Yb3+,Tm3+ inverse opal photonic crystals and NaYF4:Yb3+,Tm3+/TiO2 composites: synthesis, highly improved upconversion properties and NIR photoelectric response , 2016,杨宇丹,Journal of Materials Chemistry C,IF=5.256,工程技术1区


4. Magnetic delivery of Fe3O4@polydopamine nanoparticle-loaded natural killer cells suggest a promising anticancer treatment,2018,吴丽雅,Biomaterials Science,IF=5.251,工程技术2区


5. NF-κB Inhibition Promotes Apoptosis in Androgen-independent Prostate Cancer Cells by the Photothermal Effect via the IκBα/AR Signaling Pathway,2019,孔晨飞,姜金兰*,Biomaterials Science,IF= 5.251,工程技术2区


6. In vivo migration of Fe3O4@polydopamine nanoparticle-labeled mesenchymal stem cells to burn injury sites and their therapeutic effects in a rat model,2019,李秀英,姜金兰*,Biomaterials Science,IF= 5.251,工程技术2区


7. P-FN12, an H4R-Based Epitope Vaccine Screened by Phage Display, Regulates the Th1/Th2 Balance in Rat Allergic Rhinitis,2018,王玉倩,Mol Ther Methods Clin Dev,IF=4.875,医学2区


8. The interference of DEHP in precocious puberty of females mediated by the hypothalamic IGF-1/PI3K/Akt/mTOR signaling pathway,2019,邵浦,姜金兰*,刘特*,Ecotoxicology and Environmental Safety,IF=4.527,环境科学与生态学2区,毒理学3区


9. siRNA Delivery with Stem Cell Membrane-Coated Magnetic Nanoparticles for Imaging-Guided Photothermal Therapy and Gene Therapy,2018,李晶,ACS Biomater. Sci. Eng,IF=4.511,工程技术2区


10. Iron oxide nanoparticles promote the migration of mesenchymal stem cells to injury sites,2019,李秀英,姜金兰*,International Journal of Nanomedicine,IF=4.471,医学2区


11. Photothermal exposure of polydopamine-coated branched Au-Ag nanoparticles induces cell cycle arrest, apoptosis, and autophagy in human bladder cancer cells,2018,赵晓明,Int J Nanomedicine,IF=4.471,医学2区


12. Synthesis of ginsenoside Re-based carbon dots applied for bioimaging and effective inhibition of cancer cells,2018,姚华,Int J Nanomedicine,IF=4.471,医学2区


13. Synthesis of dual functional procaine-derived carbon dots for bioimaging and anticancer therapy,2020,赵晓明,Nanomedicine (Lond),IF=4.717,医学2区


14. EGFR-targeted delivery of DOX-loaded Fe3O4@ polydopamine multifunctional nanocomposites for MRI and antitumor chemo-photothermal therapy,2017,牟旭鹏,Int J Nanomedicine,IF=4.37,医学2区,纳米科技4区


15. Umbilical Cord Tissue-Derived Mesenchymal Stem Cells Induce T Lymphocyte Apoptosis and Cell Cycle Arrest byExpression of Indoleamine 2, 3-Dioxygenase,2016,王轶敏,李秀英,Stem Cells Int,IF=3.989,医学2区


16. Location, isolation, and identification of mesenchymal stem cells from adult human sweat glands,2018,马英智,Stem Cells International,IF=3.902,医学2区


17. Inhibition of Autophagy Promoted Apoptosis and Suppressed Growth of Hepatocellular Carcinoma Upon Photothermal Exposure,2019,王玉倩,姜金兰,Journal of Biomedical Nanotechnology,IF=4.38,医学2区


18. External magnetic field promotes the therapeutic effects of magnetically labeled bone marrow mesenchymal stem cells in laser-induced skin injuries,2019,李秀英,姜金兰*,Journal of Biomedical Nanotechnology,IF=4.38,医学2区


19. Enhanced differentiation of human amniotic fluid-derived stem cells into insulin-producing cells in vitro,2017,牟旭鹏,Journal of Diabetes Investigation,IF=3.147,医学3区


20. Seedless preparation of Au nanorods by hydroquinone assistant and red blood cell membrane camouflage,2018,李晶,RSC Adv,IF=3.049,化学3区


21. Syndecan-1 suppresses epithelial-mesenchymal transition and migration in human oral cancer,2018,孔晨飞,Oncol Rep,IF=3.041,医学3区


22. Effect of artemisinin on proliferation and apoptosis-related protein expression in vivo and in vitro,2018,郝苗,Saudi Journal of Biological Sciences,IF=2.81,医学3区


23. GRIM-19 expression is a potent prognostic marker in colorectal cancer,2015,郝苗,Human Pathology,IF=2.791,医学3区


24. Circulating microRNAs as diagnostic and prognostic tools for hepatocellular carcinoma,2015,张玉成,World Journal of Gastroenterology,IF=2.787,医学3区


25. Anti-tumor effect of adenoviral vector prime protein boost immunity targeting MUC1 VNTR,2014,王玉倩,Oncology Reports,IF=2.301,医学3区


26. Application of Nanomaterials in Stem Cell Regenerative Medicine of Orthopedic Surgery,2017,杨宇丹,Journal of Nanomaterials,IF=2.27,工程技术3区,纳米技术4区


27. The mismatch repair gene hPMS1 (human postmeiotic segregation1) is down regulated in oral squamous cell carcinoma,2013,Wang Y, Zhou X, Song Y, Ji X, Zhang A, Zhang G, Gao Z,Gene,IF=2.082,生物3区


28. Repetitive magnetic stimulation affects the microenvironment of nerve regeneration and evokedpotentials after spinal cord injury,2016,姜金兰,Neural Regen Res,IF=1.769,医学3区


29. Senegenin inhibits neuronal apoptosis after spinal cord contusion injury,2016,姜金兰,Neural Regen Res,IF=1.769,医学3区


30. Identification of appropriate reference genes for human mesenchymal stem cell analysis by quantitative real-time PCR,2015,王轶敏,李秀英,Biotechnol Lett,IF=1.639,工程技术3区


31. Human resistin inhibits myogenic differentiation and induces insulin resistance in myocytes,2013,Sheng CH, Du ZW, Song Y, Wu XD, Zhang YC, Wu M, Wang Q, Zhang GZ,Biomed Res Int,IF=1.579,生物3区


32. Effects of SARA on oxygen-glucose deprivation in PC12 cell line,2013,Wang JQ, He JT, Du ZW, Li ZS, Liu YF, Mang J, Xu ZX,Neurochemical Research,IF=1.579,医学3区


33. Comprehensive characterization of four different populations of human mesenchymal stem cells as regards their immune properties, proliferation and differentiation,2014,王轶敏,李秀英,INTERNATIONAL JOURNAL OF OLECULAR MEDICINE,IF=1.554,医学3区


34. Research of lower Limb Rehabilitation Training Gait,2016,杨宇丹,International journal of u- and a-Service,Science and Technology,IF=1.147,工程技术3区


35. Research on Patients with Depression of Facial Expression Recognition based on Facereader6 Software,2016,杨宇丹,IF=1.147,工程技术3区


36. The Effect of Photothermal Therapy on Osteosarcoma With Polyacrylic Acid–Coated Gold Nanorods. 2018,杨宇丹,Dose-Response,IF=2.451,医学4区


37. Di-(2-ethylhexyl) phthalate induces precocious puberty in adolescent female rats,2018,刘特,Iran J Basic Med Sci,IF=1.854,医学4区


38. Seedless synthesis of gold nanorods with (+)-catechin-assisted and red blood cell membranes coating as a biomimetic photothermal agents,2018,李晶,Materials Technology,IF=1.82,工程技术4区


39. Immunohistochemical expression of LAPTM4B in clear cell renal cell carcinoma by tissue microarray,2016,王玉倩,International Journal of Clinical and Experimental Pathology,IF=1.706,医学4区


40. Detecting Type 2 Diabetes- related Single Nucleotide Polymorphisms by Microarry,2013,CHEN Yan, LIU Gui Feng,LIU Xia, ZHANG GuiZhen, WANG ZhenXin,CHEMICAL JOURNAL OF CHINESE UNIVERSITIES,IF=1.579,化学4区


41. Identification of optimal reference genes for quantitative PCR studies on human mesenchymal stem cells,2015,王轶敏,李秀英,MOLECULAR MEDICINE REPORTS,IF=1.559,医学4区


42. Evaluation of eight reference genes for quantitative polymerase chain reaction analysis in human T lymphocytes co‑cultured with mesenchymal stem cells,2015,王轶敏,李秀英,Molecular Medicine Reports,IF=1.559,医学4区


43. Recombinant human decorin up-regulates p57KIP2 expression in HepG2 hepatoma cell lines,2013,张玉成,Molecular Medicine Reports,IF=1.554,医学4区


44. Recombinant human decorin upregulates p57KIP2 expression in HepG2 hepatoma cell lines,2013,Hamid AS, Li J, Wang Y, Wu X, Ali HA, Du Z, Bo L, Zhang Y, Zhang G,Mol Med Rep,IF=1.484,医学4区


45. Screening glioma stem cells in U251 cells basedon the P1 promoter of the CD133 gene,2016,张玉成,Oncology Letters,IF=1.39,医学4区


46. Study of morphological and mechanical features of multinuclear and mononuclear SW480 cells by atomic force microscopy,2018,姜金兰,Microsc Res Tech,IF=1.327,医学4区


47. Association Between Matrix Metalloproteinase-1, 2, 3 Polymorphisms and Oral Cancer Risk: A Meta-Analysis,2018,王玉倩,Genet Test Mol Biomarkers,IF=1.121,医学4区


48. Aflatoxin B1-induced hepatocellular carcinoma in developing countries: Geographical distribution, mechanism of action and prevention,2013,Hamid AS, Tesfamariam IG, Zhang Y, Zhang ZG,Oncol Lett,IF=0.987,医学4区


49. Aflatoxin B1-induced hepatocellular carcinoma in developing countries: Geographical distribution, mechanism of action and prevention,2013,张玉成,Oncol Lett,IF= 0.987,医学4区


50. Geniposide protects against spinal cord injury in rats through attenuating the regulation of inflammatory response and the Bcl2/Bax pathway. 2018,杨宇丹,Int J Clin Exp Med,IF=0.181,医学4区


51. Identification and Classification of Electroencephalogram Signals Based on Independent Component Analysis.2018,杨宇丹,NeuroQuantology,IF=0,医学4区


科研中心在研项目情况


1. 脐带间充质干细胞在动脉粥样硬化预防及治疗中的研究 2019-2021 吉林省科技发展计划项目 15万 张福强


2. 吉林省老年退行性疾病多尺度精准诊疗重点实验室 2019-2021 吉林省科技发展计划项目 50万 姜金兰


3. 人脐带间充质干细胞治疗阿尔茨海默病的临床研究 2019-2021 科技创新专项资金项目-医药办 50万 姜金兰


4. 吉林省质谱精准医疗研究科技创新中心 2019-2021 吉林省科技发展计划项目 50万 姜金兰


5. 吉林省个体化细胞治疗创新工程实验室 2019-2021 2019年省预算内基本建设资金(创新能力建设-高技术产业部分)计划项目20万 姜金兰


6. 脐带间充质干细胞在动脉粥样硬化预防及治疗中的研究 2019-2021 吉林省科技发展计划项目 15万 张福强


7. 四氧化三铁纳米粒子标记间充质干细胞治疗帕金森病的研究 2018-2021 吉林省省直卫生专项项目 10万 姜金兰


8. 脐带间充质干细胞在动脉粥样硬化及治疗中的研究 2019-2020. 吉林省科技厅国际合作项目 15万 张福强


9. 下丘脑IGF-1信号介导DEHP致雌性性早熟的机制研究 2019-2020 吉林省教育厅 2.5万 刘特


10. GRIM-19下调通过非STAT3依赖途径诱导结肠癌细胞自噬的机制研究 2019-2020 吉林省教育厅“十三五”科学技术研究规划项目 2.5万 郝苗


11. 干细胞膜包裹人参皂苷纳米药物传递系统的制备及抗肿瘤作用评价 2019-2020 吉林省教育厅项目 2.5万 姚华


12. 基于IGF-1/NKB信号系统crosstalk探讨DEHP上调下丘脑GnRH诱导雌性性早熟的分子机制 2019-2020 吉林省科技厅优秀青年人才基金项目 7万 刘特


13. GRIM-19下调通过非STAT3依赖途径诱导结肠癌细胞自噬的机制研究 2019-2020 吉林省科技厅优秀青年人才基金项目 7万 郝苗


14. 人脐带间充质干细胞治疗类风湿关节炎注射液的开发 2018-2020 长春市科技发展计划项目 200万 姜金兰


15. LincRNA-ROR通过活化ZEB1通路促进结肠癌转移的作用及机制研究 2018-2020 吉林大学白求恩计划 10万 孔晨飞


16. 精准细胞治疗临床应用评价标准体系的建立 2017-2020 横向课题 200万 姜金兰


17. 吉林省精准细胞诊疗重点实验室建设项目 2017-2020 吉林省财政厅 300万 姜金兰‍